Automated foam control in single-use bioreactors using the single use foam probe

摘要

Stainless steel reactors typicaiiy employ mechanical foam breaker (microbial), this is difficult to translate into a scalable solution. Chemical de foaming agents are required. Many types of antifoam emulsions are available that are either autoclave friendly often requiring dilution or irradiated in a ready to use format. Typically antifoam is dosed in a very manual manner. Dosing based on time/volume or when the operator observers a particular level of foam in the vessel is not uncommon.