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Multimodal ophthalmic imaging using handheld spectrally encoded coherence tomography and reflectometry (SECTR)

机译:使用手持式光谱编码相干层析成像和反射法(SECTR)的多峰眼科成像

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Scanning laser ophthalmoscopy (SLO) provides high-speed, noninvasive en face imaging of the retinal fundus. Optical coherence tomography (OCT) is the current 'gold-standard' for ophthalmic diagnostic imaging and enables depth-resolved visualization of ophthalmic structures and image-based surrogate biomarkers of disease. We present a compact optical and mechanical design for handheld spectrally encoded coherence tomography and reflectometry (SECTR) for multimodality en face spectrally encoded reflectometry (SER) and cross-sectional OCT imaging. We custom-designed a double-pass telecentric scan lens, which halves the size of 4-f optical relays and allowed us to reduce the footprint of our SECTR scan-head by a factor of >2.7x (volume) over our previous design. The double-pass scan lens was optimized for diffraction-limited performance over a ±10° scan field. SECTR optics and optomechanics were combined in a compact rapid-prototyped enclosure with dimensions 87 × 141.8 × 137 mm (w × h × d). SECTR was implemented using a custom-built 400 kHz 1050 nm swept-source. OCT and SER were simultaneously digitized on dual input channels of a 4 GS/s digitizer at 1.4 GS/s per channel. In vivo human en face SER and cross-sectional OCT images were acquired at 350 fps. OCT volumes of 1000 B-scans were acquired in 2.86 s. We believe clinical translation of our compact handheld design will benefit point-of-care ophthalmic diagnostics in patients who are unable to be imaged on conventional slit-lamp based systems, such as infants and the bedridden. When combined with multi-volumetric registration methods, handheld SECTR will have advantages in motion-artifact free imaging over existing handheld technologies.
机译:扫描激光检眼镜(SLO)提供了视网膜眼底的高速,无创面部成像。光学相干断层扫描(OCT)是眼科诊断成像的当前“黄金标准”,可实现眼科结构的深度解析可视化以及基于图像的疾病替代生物标记。我们提出了一种紧凑的光学和机械设计,用于手持式光谱编码相干层析成像和反射法(SECTR),用于多模态面谱编码反射法(SER)和截面OCT成像。我们定制设计了一个双通远心扫描透镜,该透镜使4-f光学继电器的尺寸减半,并使我们的SECTR扫描头的占地面积比以前的设计减少了> 2.7倍(体积)。针对在±10°扫描范围内的衍射极限性能进行了优化的双通扫描透镜。 SECTR光学器件和光机械器件组合在一个紧凑的快速原型外壳中,尺寸为87×141.8×137 mm(w×h×d)。 SECTR是使用定制的400 kHz 1050 nm扫频光源实现的。 OCT和SER同时在4 GS / s数字转换器的双输入通道上以每通道1.4 GS / s的速度进行数字化。以350 fps的速度获取体内人脸SER和横截面OCT图像。在2.86 s内获得了1000次B扫描的OCT量。我们相信,紧凑型手持设计的临床翻译将为无法在基于常规裂隙灯的系统上成像的患者(如婴儿和卧床不起)的患者提供即时医疗眼科诊断服务。当与多体积配准方法结合使用时,手持式SECTR在无运动伪影的成像方面将比现有手持技术具有优势。

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