Wide Field-of-View High Lateral Resolution Optical Coherence Tomography with 3D Image Stitching and Superresolution

摘要

We report that wide field-of-view (FOV) optical coherence tomography images with high lateral resolution can be obtained by using superresolution and 3D image stitching techniques. About 3 times lateral resolution improvement from 6.20 urn to 2.19 μm using a focusing lens of 0.08 numerical aperture has been demonstrated. With such lens the FOV is generally small owing to off-axis focusing degradation. To enlarge the FOV while maintaining high lateral resolution, 3D image stitching technique is introduced to effectively reconstruct an ultra-wide FOV 3D image of 2.10×1.15 mm~2 lateral area from ten C-scans of 500×500 μm~2 FOV. Improved FOV with high lateral resolution should benefit various biomedical imaging applications.