Biomedical Informatics; New Insights in Next Generation of Clinical and Basic Human Biological Sciences

摘要

The mechanisms of many diseases are not well known. Because of that a lot of materials and drugs are utilized in medical fields without any useful reason. The ambiguous unsolved problems are time-consuming for physicians and make the treatment processes hard. Many people suffer from the invasive treatments because the mechanism of their illness is not well known and, consequently, there is no effective drug or treatment method against their medical problem. Todays, with the help of Biomedical informatics (BMI) as a new multi-purposes interdisciplinary science, application of biomedical knowledge and information to improve patient care and medical sciences research are facilitated. Study on cellular and/or molecular modeling and simulation, drug design, docking and computational biochemistry, sequence analysis, analysis of gene expression and regulation, protein expression, mutations in cancer are some parameter that are facilitated by such Bioinformatical approaches. Our research lines focus on clinical investigations in combination to Biomedical informatics. The mechanisms of unknown errors of bone formation, hormonal malfunctions, consequently, drug design and docking are the main topics of interests. The main ways to join computer sciences to molecular medical sciences will be explained and a new insight into Heterotopic ossification by focusing on the role of Transforming growth factor - β super family, as well as the main biomedical causes of Adolescent idiopathic scoliosis (AIS) will be presented as two examples.