A New Invention Process of Manufacturing a Softgel Capsule Probiotics as Pre-Healthy Medicine

摘要

Recent scientific investigation has supported the important role of probiotics as a part of a healthy medicine for human and may be an avenue to provide a safe, cost effective, and 'natural' approach that adds a barrier against microbial infection. The stability, viability and quality of products containing probiotic bacteria have been problematic, therefore This paper presents a new invention process of manufacturing a softgel capsule probiotics as pre-healthy medicine, health maintenance and disease prevention. Materials and methods: The present invention is directed to a process of manufacturing o softgel capsules containing microencapsulated probiotic bacteria comprising the steps of; (a) providing microencapsulated probiotic bacteria with at least coating, at least vegetable lipid having a melting point of between 35 and 75 degree centigrade; (b) suspending it in a suspending formulation to make it fill; (c) mixing the fill at low intensity and low temperature to make a mixed fill; (d) reducing agglomerates of microencapsulated probiotic bacteria; (e) encapsulating the de-agglomerated fill in a softgel capsule. Then it was surveyed the stability of capsules under defined conditions. Results: The invention relates to a process of manufacturing a softgel capsule containing microencapsulated probiotic bacteria and to the product made according to this process. More specifically, the product of the invention is stable at room temperature for at least 24 months.