Synthesis and Acaricidal Activity of Novel 2-Substituted-3-trifluoromethylquinoxalines

摘要

Recently fluorine-containing compounds have attained importance as a target for useful agrochemicals. The 2-substituted-3-trifluoromethylquinoxalines are a novel type of fluorine containing compounds designed and synthesized by our group, which exhibit excellent acaricidal and insecticidal activities. The reaction of o-phenylenediamine with ethyl trifluoropyruvate as a fluorine source, followed by chlorination leads to a common starting material for the aimed fluorine-containing chemicals. The reaction of the starting material with different types of nucleophiles such as amines gave a wide variety of 2-substituted-3-trifluoromethylquinoxalines. Some of the compounds synthesized showed excellent acaricidal activity against two-spotted spider mites (Tetranychus urticae), and some other compounds, in turn exhibited insecticidal activity.