Substrate stiffness reguates cellular uptake of nanoparticles

摘要

Nanoparticle-bioconjugates hold great promise for more sensitive disease diagnosis and more effective anticancer drug delivery compared with existing approaches.A critical aspect in both applications is cellular internalization of nanoparticles,which is influenced by nanoparticle properties and cell surface mechanics.Despite considerable progress in the optimization of the nanoparticlebionconjugates for improved targeting,the role of substrate stiffness on cellular uptake has not been investigated.